Marc Simon, MD, MS

Professor in Residence
Medicine
[email protected]
+1 415 502-8584

CLINICAL INTERESTS: Dr. Simon is director of Pulmonary Vascular Disease and the Pulmonary Hypertension Comprehensive Care Center. He has expertise as a cardiologist specializing in pulmonary hypertension, advanced heart failure, and heart transplantation.

RESEARCH INTERESTS: Dr. Simon’s research primary research focus involves developing new therapies for pulmonary hypertension and better understanding right-sided heart failure in pulmonary hypertension (PH). Notably, right-sided heart failure and PH are associated with poor outcomes and in particular have been noted to occur in another type of heart failure, called heart failure with preserved ejection fraction or HFpEF, in which the heart seems to function normally but causes difficulty breathing due to a stiffening of the heart and blood vessels.

Publications: 

The uses of right heart catheterization in cardio-pulmonary disease: State-of-the-art.

American heart journal plus : cardiology research and practice

Katbamna B, Wu L, Rodriguez M, King P, Schilling J, Mahar J, Nair AP, Jneid H, Klings ES, Weinhouse GL, Mazimba S, Simon MA, Strauss M, Krittanawong C

Exploring the Noninvasive Evaluation of the Pulmonary Pressure-Flow Relationship During Exercise.

Journal of the American Heart Association

Andersen MJ, Vase H, Simon MA

Plasma Proteomics Identifies B2M as a Regulator of Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction.

Arteriosclerosis, thrombosis, and vascular biology

Jheng JR, DesJardin JT, Chen YY, Huot JR, Bai Y, Cook T, Hibbard LM, Rupp JM, Fisher A, Zhang Y, Duarte JD, Desai AA, Machado RF, Simon MA, Lai YC

Skeletal Muscle SIRT3 Deficiency Contributes to Pulmonary Vascular Remodeling in Pulmonary Hypertension Due to Heart Failure With Preserved Ejection Fraction.

Circulation

Jheng JR, Bai Y, Noda K, Huot JR, Cook T, Fisher A, Chen YY, Goncharov DA, Goncharova EA, Simon MA, Zhang Y, Forman DE, Rojas M, Machado RF, Auwerx J, Gladwin MT, Lai YC

Beta blockers are associated with lower all-cause mortality among HFpEF patients.

Clinical research in cardiology : official journal of the German Cardiac Society

Ibrahim J, Fabrizio C, Sezer A, Thoma F, Boyle B, Mulukutla SR, Huston JH, Simon MA, Hickey GW

Pulmonary artery compliance in different forms of pulmonary hypertension.

Heart (British Cardiac Society)

McCormick A, Krishnan A, Badesch D, Benza RL, Bull TM, De Marco T, Feldman J, Hemnes AR, Hirsch R, Horn E, Kennedy J, Mathai SC, McConnell W, Pugliese SC, Sager JS, Shlobin OA, Simon MA, Lammi MR

Knowing All the Angles (on Right Ventricular Myocardial Remodeling).

Circulation. Heart failure

Simon MA, Cormack JM, Sharifi Kia D

The Lung Allocation Score Remains Inequitable for Patients with Pulmonary Arterial Hypertension, Even after the 2015 Revision.

American journal of respiratory and critical care medicine

Kolaitis NA, Chen H, Calabrese DR, Kumar K, Obata J, Bach C, Golden JA, Simon MA, Kukreja J, Hays SR, Leard LE, Singer JP, De Marco T

Erratum: Health disparities and treatment approaches in portopulmonary hypertension and idiopathic pulmonary arterial hypertension: An analysis of the Pulmonary Hypertension Association Registry.

Pulmonary circulation

DuBrock HM, Burger CD, Bartolome SD, Feldman JP, Ivy DD, Rosenzweig EB, Sager JS, Presberg KW, Mathai SC, Lammi MR, Klinger JR, Eggert M, De Marco T, Elwing JM, Badesch D, Bull TM, Cadaret LM, Ramani G, Thenappan T, Ford HJ, Al-Naamani N, Simon MA, Mazimba S, Runo JR, Chakinala M, Horn EM, Ryan JJ, Frantz RP, Krowka MJ, PHAR Investigators

Anticoagulation in pulmonary arterial hypertension - association with mortality, healthcare utilization, and quality of life: The Pulmonary Hypertension Association Registry (PHAR).

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Garry JD, Kolaitis NA, Kronmal R, Thenappan T, Hemnes A, Grinnan D, Bull T, Chakinala MM, Horn E, Simon MA, De Marco T, Pulmonary Hypertension Association Registry Investigators

HIV-associated Pulmonary Arterial Hypertension: A Report from the Pulmonary Hypertension Association Registry.

American journal of respiratory and critical care medicine

Kolaitis NA, Lammi M, Mazimba S, Feldman J, McConnell W, Sager JS, Raval AA, Simon MA, De Marco T

Aggressive Afterload Lowering to Improve the Right Ventricle: A New Target for Medical Therapy in Pulmonary Arterial Hypertension?

American journal of respiratory and critical care medicine

Vizza CD, Lang IM, Badagliacca R, Benza RL, Rosenkranz S, White RJ, Adir Y, Andreassen AK, Balasubramanian V, Bartolome S, Blanco I, Bourge RC, Carlsen J, Camacho REC, D'Alto M, Farber HW, Frantz RP, Ford HJ, Ghio S, Gomberg-Maitland M, Humbert M, Naeije R, Orfanos SE, Oudiz RJ, Perrone SV, Shlobin OA, Simon MA, Sitbon O, Torres F, Luc Vachiery J, Wang KY, Yacoub MH, Liu Y, Golden G, Matsubara H

Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation

JACC: Basic to Translational Science

Mehra R, Tjurmina OA, Ajijola OA, Arora R, Bolser DC, Chapleau MW, Chen P-S, Clancy CE, Delisle BP, Gold MR, Goldberger JJ, Goldstein DS, Habecker BA, Handoko ML, Harvey R, Hummel JP, Hund T, Meyer C, Redline S, Ripplinger CM, Simon MA, Somers VK, Stavrakis S, Taylor-Clark T, Undem BJ, Verrier RL, Zucker IH, Sopko G, Shivkumar K.

Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop.

JACC. Basic to translational science

Mehra R, Tjurmina OA, Ajijola OA, Arora R, Bolser DC, Chapleau MW, Chen PS, Clancy CE, Delisle BP, Gold MR, Goldberger JJ, Goldstein DS, Habecker BA, Handoko ML, Harvey R, Hummel JP, Hund T, Meyer C, Redline S, Ripplinger CM, Simon MA, Somers VK, Stavrakis S, Taylor-Clark T, Undem BJ, Verrier RL, Zucker IH, Sopko G, Shivkumar K

An open-label, dose-escalation study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of GSK2586881 in participants with pulmonary arterial hypertension.

Pulmonary circulation

Simon MA, Hanrott K, Budd DC, Torres F, Grünig E, Escribano-Subias P, Meseguer ML, Halank M, Opitz C, Hall DA, Hewens D, Powley WM, Siederer S, Bayliffe A, Lazaar AL, Cahn A, Rosenkranz S

The Effects of Healthy Aging on Right Ventricular Structure and Biomechanical Properties: A Pilot Study.

Frontiers in medicine

Sharifi Kia D, Shen Y, Bachman TN, Goncharova EA, Kim K, Simon MA

An open-label, dose-escalation study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of GSK2586881 in participants with pulmonary arterial hypertension

Pulmonary circulation

Simon MA, Hanrott K, Budd DC, Torres F, Grünig E, Escribano-Subias P, Meseguer ML, Halank M, Opitz C, Hall DA, Hewens D, Powley WM, Siederer S, Bayliffe A, Lazaar AL, Cahn A, Rosenkranz S

A clinically applicable strategy to estimate the in vivo distribution of mechanical material properties of the right ventricular wall.

International journal for numerical methods in biomedical engineering

Xu J, Wong TC, Simon MA, Brigham JC

Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction: JACC State-of-the-Art Review.

Journal of the American College of Cardiology

Pandey A, Shah SJ, Butler J, Kellogg DL, Lewis GD, Forman DE, Mentz RJ, Borlaug BA, Simon MA, Chirinos JA, Fielding RA, Volpi E, Molina AJA, Haykowsky MJ, Sam F, Goodpaster BH, Bertoni AG, Justice JN, White JP, Ding J, Hummel SL, LeBrasseur NK, Taffet GE, Pipinos II, Kitzman D

Role of Internal Jugular Venous Ultrasound in suspected or confirmed Heart Failure: A Systematic Review.

Journal of Cardiac Failure

Chaudhary R, Sukhi A, Simon MA, Villanueva FS, Pacella JJ

Pulmonary Hypertension in the Context of Heart Failure With Preserved Ejection Fraction.

Chest

Inampudi C, Silverman D, Simon MA, Leary PJ, Sharma K, Houston BA, Vachiéry JL, Haddad F, Tedford RJ

Gender Differences in Mortality After Left Ventricular Assist Device Implant: A Causal Mediation Analysis Approach.

ASAIO journal (American Society for Artificial Internal Organs : 1992)

Nayak A, Hu Y, Ko YA, Mehta A, Liu C, Pennington J, Xie R, Cowger J, Kirklin JK, Kormos RL, Simon MA, Morris AA

A Pilot Study of Dimethyl Fumarate in Pulmonary Arterial Hypertension Associated with Systemic Sclerosis.

Journal of scleroderma and related disorders

Kong K, Koontz D, Morse C, Roth E, Domsic RT, Simon MA, Stratton E, Buchholz C, Tobin-Finch K, Simms R, George MP, Hassoun PM, Farber H, Lafyatis R

Health disparities and treatment approaches in portopulmonary hypertension and idiopathic pulmonary arterial hypertension: an analysis of the Pulmonary Hypertension Association Registry.

Pulmonary circulation

DuBrock HM, Burger CD, Bartolome SD, Feldman JP, Ivy DD, Rosenzweig EB, Sager JS, Presberg KW, Mathai SC, Lammi MR, Klinger JR, Eggert M, De Marco T, Elwing JM, Badesch D, Bull TM, Cadaret LM, Ramani G, Thenappan T, Ford HJ, Al-Naamani N, Simon MA, Mazimba S, Runo JR, Chakinala M, Horn EM, Ryan JJ, Frantz RP, Krowka MJ

Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH.

Genome medicine

Zhu N, Swietlik EM, Welch CL, Pauciulo MW, Hagen JJ, Zhou X, Guo Y, Karten J, Pandya D, Tilly T, Lutz KA, Martin JM, Treacy CM, Rosenzweig EB, Krishnan U, Coleman AW, Gonzaga-Jauregui C, Lawrie A, Trembath RC, Wilkins MR, Regeneron Genetics Center, PAH Biobank Enrolling Centers’ Investigators, NIHR BioResource for Translational Research - Rare Diseases, National Cohort Study of Idiopathic and Heritable PAH, Morrell NW, Shen Y, Gräf S, Nichols WC, Chung WK

Semi-Automated Graphical System for Calculating Pulmonary Vascular Impedances in a Clinical Setting

IEEE Open Journal of Engineering in Medicine and Biology

Bachman TN, Kim K, Simon MA

Levosimendan Improves Hemodynamics and Exercise Tolerance in PH-HFpEF: Results of the Randomized Placebo-Controlled HELP Trial.

JACC. Heart failure

Burkhoff D, Borlaug BA, Shah SJ, Zolty R, Tedford RJ, Thenappan T, Zamanian RT, Mazurek JA, Rich JD, Simon MA, Chung ES, Raza F, Majure DT, Lewis GD, Preston IR, Rich S

Clinical Differences and Outcomes between Methamphetamine-associated and Idiopathic Pulmonary Arterial Hypertension in the Pulmonary Hypertension Association Registry.

Annals of the American Thoracic Society

Kolaitis NA, Zamanian RT, de Jesus Perez VA, Badesch DB, Benza RL, Burger CD, Chakinala MM, Elwing JM, Feldman J, Lammi MR, Mathai SC, McConnell JW, Presberg KW, Robinson JC, Sager J, Shlobin OA, Simon MA, Kawut SM, Glidden DV, Singer JP, De Marco T, Pulmonary Hypertension Association Registry Investigators

Creation and Validation of a Novel Sex-Specific Mortality Risk Score in LVAD Recipients.

Journal of the American Heart Association

Nayak A, Hu Y, Ko YA, Steinberg R, Das S, Mehta A, Liu C, Pennington J, Xie R, Kirklin JK, Kormos RL, Cowger J, Simon MA, Morris AA

The Prognostic Value of Right Atrial Strain Imaging in Patients with Precapillary Pulmonary Hypertension.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

Hasselberg NE, Kagiyama N, Soyama Y, Sugahara M, Goda A, Ryo-Koriyama K, Batel O, Chakinala M, Simon MA, Gorcsan J

Prediction of Health-related Quality of Life and Hospitalization in Pulmonary Arterial Hypertension: The Pulmonary Hypertension Association Registry.

American journal of respiratory and critical care medicine

Min J, Badesch D, Chakinala M, Elwing J, Frantz R, Horn E, Klinger J, Lammi M, Mazimba S, Sager J, Shlobin O, Simon M, Thenappan T, Grinnan D, Ventetuolo C, Al-Naamani N, PHAR Investigators

Association between Preoperative Dynamic Measures of Vascular Load and Postoperative Hemodynamics in Patients with Chronic Thromboembolic Pulmonary Hypertension after Pulmonary Thromboendarterectomy.

Annals of the American Thoracic Society

Contijoch F, Wong D, Igata S, Mizzell AM, Auger W, DeMaria AN, Blanchard D, Waheed A, Bachman TN, Simon MA, Pinsky MR, Madani M

The Preimplantation Psychosocial Evaluation and Prediction of Clinical Outcomes During Mechanical Circulatory Support: What Information Is Most Prognostic?

Transplantation

Dew MA, Hollenberger JC, Obregon LL, Hickey GW, Sciortino CM, Lockard KL, Kunz NM, Mathier MA, Ramani RN, Kilic A, McNamara DM, Simon MA, Keebler ME, Kormos RL

Right ventricular load and contractility in HIV-associated pulmonary hypertension.

PloS one

Rajaratnam A, Rehman S, Sharma P, Singh VK, Saul M, Vanderpool RR, Gladwin MT, Simon MA, Morris A

A pilot study of oral treprostinil pharmacogenomics and treatment persistence in patients with pulmonary arterial hypertension.

Therapeutic advances in respiratory disease

Coons JC, Crisamore K, Adams S, Modany A, Simon MA, Zhao W, Shaik IH, Venkataramanan R, Empey PE

Induced bioresistance via BNP detection for machine learning-based risk assessment.

Biosensors & bioelectronics

So S, Khalaf A, Yi X, Herring C, Zhang Y, Simon MA, Akcakaya M, Lee S, Yun M

SCUBE1 Controls BMPR2-Relevant Pulmonary Endothelial Function: Implications for Diagnostic Marker Development in Pulmonary Arterial Hypertension.

JACC. Basic to translational science

Sun W, Tang Y, Tai YY, Handen A, Zhao J, Speyer G, Al Aaraj Y, Watson A, Romanelli ME, Sembrat J, Rojas M, Simon MA, Zhang Y, Lee J, Xiong Z, Dutta P, Vasamsetti SB, McNamara D, McVerry B, McTiernan CF, Sciurba FC, Kim S, Smith KA, Mazurek JA, Han Y, Vaidya A, Nouraie SM, Kelly NJ, Chan SY

Obesity in Pulmonary Arterial Hypertension (PAH): The Pulmonary Hypertension Association Registry (PHAR).

Annals of the American Thoracic Society

Min J, Feng R, Badesch D, Berman-Rosenzweig E, Burger C, Chakinala M, De Marco T, Feldman J, Hemnes A, Horn EM, Lammi MR, Mathai S, McConnell JW, Presberg K, Robinson J, Sager J, Shlobin OA, Simon M, Thenappan T, Ventetuolo C, Al-Naamani N, PHAR Investigators

Nationwide variability in the use of induction immunosuppression for adult heart transplantation.

Journal of cardiac surgery

Diaz-Castrillon CE, Seese L, Mathier MA, Keebler ME, Hickey GW, McNamara D, Simon MA, Horn E, Kilic A

PROVIDE-HF primary results: Patient-Reported Outcomes inVestigation following Initiation of Drug therapy with Entresto (sacubitril/valsartan) in heart failure.

American heart journal

Mentz RJ, Xu H, O'Brien EC, Thomas L, Alexy T, Gupta B, Vilaro J, Lala A, DeVore AD, Dhingra R, Briasoulis A, Simon MA, Stehlik J, Rodgers JE, Dunlay SM, Abshire M, Wells QS, Barringhaus KG, Eckman PM, Lowes BD, Espinoza J, Blanco R, Shen X, Duffy CI, Hernandez AF

Diversity, Equity, and Inclusiveness in Medicine and Cardiology: Next Steps for JAHA.

Journal of the American Heart Association

London B, Ahmad F, Eitzman DT, Gupta AK, Jneid H, Peterson P, Remme CA, Rice K, Schelbert EB, Simon MA, Sullivan LM, Weinberg JM

Equity, Diversity, and Inclusiveness in Cardiovascular Medicine and Health Care.

Journal of the American Heart Association

Simon MA, Ahmad F, Eitzman DT, Gupta AK, Jneid H, Peterson P, Remme CA, Rice K, Schelbert EB, Sullivan LM, Weinberg JM

J Am Heart Assoc

Equity, Diversity, and Inclusiveness in Cardiovascular Medicine and Health Care

Simon MA, Ahmad F, Eitzman DT, Gupta AK, Jneid H, Peterson P, Remme CA, Rice K, Schelbert EB, Sullivan LM, Weinberg JM

United States Pulmonary Hypertension Scientific Registry: Baseline Characteristics.

Chest

Badlam JB, Badesch DB, Austin ED, Benza RL, Chung WK, Farber HW, Feldkircher K, Frost AE, Poms AD, Lutz KA, Pauciulo MW, Yu C, Nichols WC, Elliott CG, USPHSR Investigators

Metformin in Pulmonary Hypertension in Left Heart Disease.

Frontiers in medicine

Mulkareddy V, Simon MA

Angiotensin Receptor-Neprilysin Inhibition Attenuates Right Ventricular Remodeling in Pulmonary Hypertension.

Journal of the American Heart Association

Sharifi Kia D, Benza E, Bachman TN, Tushak C, Kim K, Simon MA

mTORC1 in Pulmonary Arterial Hypertension. At the Crossroads between Vasoconstriction and Vascular Remodeling?

American journal of respiratory and critical care medicine

Goncharova EA, Simon MA, Yuan JX

Outcomes of Pulmonary Arterial Hypertension Are Improved in a Specialty Care Center.

Chest

Pi H, Kosanovich CM, Handen A, Tao M, Visina J, Vanspeybroeck G, Simon MA, Risbano MG, Desai A, Mathier MA, Rivera-Lebron BN, Nguyen Q, Kliner J, Nouraie M, Chan SY

Usefulness of regional right ventricular and right atrial strain for prediction of early and late right ventricular failure following a left ventricular assist device implant: A machine learning approach.

The International journal of artificial organs

Bellavia D, Iacovoni A, Agnese V, Falletta C, Coronnello C, Pasta S, Novo G, di Gesaro G, Senni M, Maalouf J, Sciacca S, Pilato M, Simon M, Clemenza F, Gorcsan SJ

Novel risk genes and mechanisms implicated by exome sequencing of 2572 individuals with pulmonary arterial hypertension.

Genome medicine

Zhu N, Pauciulo MW, Welch CL, Lutz KA, Coleman AW, Gonzaga-Jauregui C, Wang J, Grimes JM, Martin LJ, He H, PAH Biobank Enrolling Centers’ Investigators, Shen Y, Chung WK, Nichols WC

Pulmonary Hypertension in Patients with Heart Failure with Preserved Ejection Fraction. Where to Draw the Line.

American journal of respiratory and critical care medicine

Simon MA, Maron BA

Alterations in platelet bioenergetics in Group 2 PH-HFpEF patients.

PloS one

Nguyen QL, Wang Y, Helbling N, Simon MA, Shiva S

Current and Future Considerations in the Use of Mechanical Circulatory Support Devices: An Update, 2008-2018.

Annual review of biomedical engineering

Simon MA, Bachman TN, Watson J, Baldwin JT, Wagner WR, Borovetz HS

Distinct plasma gradients of microRNA-204 in the pulmonary circulation of patients suffering from WHO Groups I and II pulmonary hypertension.

Pulmonary circulation

Estephan LE, Genuardi MV, Kosanovich CM, Risbano MG, Zhang Y, Petro N, Watson A, Al Aaraj Y, Sembrat JC, Rojas M, Goncharov DA, Simon MA, Goncharova EA, Vaidya A, Smith A, Mazurek J, Han Y, Chan SY

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.

The Lancet. Respiratory medicine

Rhodes CJ, Batai K, Bleda M, Haimel M, Southgate L, Germain M, Pauciulo MW, Hadinnapola C, Aman J, Girerd B, Arora A, Knight J, Hanscombe KB, Karnes JH, Kaakinen M, Gall H, Ulrich A, Harbaum L, Cebola I, Ferrer J, Lutz K, Swietlik EM, Ahmad F, Amouyel P, Archer SL, Argula R, Austin ED, Badesch D, Bakshi S, Barnett C, Benza R, Bhatt N, Bogaard HJ, Burger CD, Chakinala M, Church C, Coghlan JG, Condliffe R, Corris PA, Danesino C, Debette S, Elliott CG, Elwing J, Eyries M, Fortin T, Franke A, Frantz RP, Frost A, Garcia JGN, Ghio S, Ghofrani HA, Gibbs JSR, Harley J, He H, Hill NS, Hirsch R, Houweling AC, Howard LS, Ivy D, Kiely DG, Klinger J, Kovacs G, Lahm T, Laudes M, Machado RD, MacKenzie Ross RV, Marsolo K, Martin LJ, Moledina S, Montani D, Nathan SD, Newnham M, Olschewski A, Olschewski H, Oudiz RJ, Ouwehand WH, Peacock AJ, Pepke-Zaba J, Rehman Z, Robbins I, Roden DM, Rosenzweig EB, Saydain G, Scelsi L, Schilz R, Seeger W, Shaffer CM, Simms RW, Simon M, Sitbon O, Suntharalingam J, Tang H, Tchourbanov AY, Thenappan T, Torres F, Toshner MR, Treacy CM, Vonk Noordegraaf A, Waisfisz Q, Walsworth AK, Walter RE, Wharton J, White RJ, Wilt J, Wort SJ, Yung D, Lawrie A, Humbert M, Soubrier F, Trégouët DA, Prokopenko I, Kittles R, Gräf S, Nichols WC, Trembath RC, Desai AA, Morrell NW, Wilkins MR, UK NIHR BioResource Rare Diseases Consortium, UK PAH Cohort Study Consortium, US PAH Biobank Consortium

Longitudinal Evaluation of Pulmonary Arterial Hypertension in a Rhesus Macaque (Macaca mulatta) Model of HIV Infection.

Comparative medicine

Tarantelli RA, Schweitzer F, Simon MA, Vanderpool RR, Christman I, Rayens E, Kling HM, Zullo T, Carney JP, Lopresti BJ, Bertero T, Chan SY, Norris KA

Hemolysis-induced Lung Vascular Leakage Contributes to the Development of Pulmonary Hypertension.

American journal of respiratory cell and molecular biology

Rafikova O, Williams ER, McBride ML, Zemskova M, Srivastava A, Nair V, Desai AA, Langlais PR, Zemskov E, Simon M, Mandarino LJ, Rafikov R

Pulmonary vascular disease in the setting of heart failure with preserved ejection fraction.

Trends in cardiovascular medicine

Levine AR, Simon MA, Gladwin MT

Right ventricle to pulmonary artery coupling in patients undergoing transcatheter aortic valve implantation.

Heart (British Cardiac Society)

Sultan I, Cardounel A, Abdelkarim I, Kilic A, Althouse AD, Sharbaugh MS, Gupta A, Xu J, Fukui M, Simon MA, Schindler JT, Lee JS, Gleason TG, Cavalcante JL

Impact of four times daily dosing of oral treprostinil on tolerability and daily dose achieved in pulmonary hypertension.

Pulmonary circulation

Coons JC, Bunner C, Ishizawar DC, Risbano MG, Rivera-Lebron B, Mathier MA, Chan SY, Simon MA

Bosentan-based, treat-to-target therapy in patients with pulmonary arterial hypertension: results from the COMPASS-3 study.

Pulmonary circulation

Benza RL, Raina A, Gupta H, Murali S, Burden A, Zastrow MS, Park MH, Simon MA

Biomechanical and Hemodynamic Measures of Right Ventricular Diastolic Function: Translating Tissue Biomechanics to Clinical Relevance.

Journal of the American Heart Association

Jang S, Vanderpool RR, Avazmohammadi R, Lapshin E, Bachman TN, Sacks M, Simon MA

Temporal Relation Between Myocardial Fibrosis and Heart Failure With Preserved Ejection Fraction: Association With Baseline Disease Severity and Subsequent Outcome.

JAMA cardiology

Schelbert EB, Fridman Y, Wong TC, Abu Daya H, Piehler KM, Kadakkal A, Miller CA, Ugander M, Maanja M, Kellman P, Shah DJ, Abebe KZ, Simon MA, Quarta G, Senni M, Butler J, Diez J, Redfield MM, Gheorghiade M

How prostacyclin therapy improves right ventricular function in pulmonary arterial hypertension.

The European respiratory journal

Vanderpool RR, Desai AA, Knapp SM, Simon MA, Abidov A, Yuan JX, Garcia JGN, Hansen LM, Knoper SR, Naeije R, Rischard FP

Platelets from pulmonary hypertension patients show increased mitochondrial reserve capacity.

JCI insight

Nguyen QL, Corey C, White P, Watson A, Gladwin MT, Simon MA, Shiva S

Comprehensive Right-Sided Assessment for Transcatheter Aortic Valve Replacement Risk Stratification: Time for a Change.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

Cavalcante JL, Simon MA, Chan SY

Chemokine receptor patterns and right heart failure in mechanical circulatory support.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Nayak A, Neill C, Kormos RL, Lagazzi L, Halder I, McTiernan C, Larsen J, Inashvili A, Teuteberg J, Bachman TN, Hanley-Yanez K, McNamara DM, Simon MA

Acute hemodynamic effects of inhaled sodium nitrite in pulmonary hypertension associated with heart failure with preserved ejection fraction.

JCI insight

Simon MA, Vanderpool RR, Nouraie M, Bachman TN, White PM, Sugahara M, Gorcsan J, Parsley EL, Gladwin MT

A novel constitutive model for passive right ventricular myocardium: evidence for myofiber-collagen fiber mechanical coupling.

Biomechanics and modeling in mechanobiology

Avazmohammadi R, Hill MR, Simon MA, Zhang W, Sacks MS

Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension.

The Journal of clinical investigation

Bertero T, Oldham WM, Cottrill KA, Pisano S, Vanderpool RR, Yu Q, Zhao J, Tai Y, Tang Y, Zhang YY, Rehman S, Sugahara M, Qi Z, Gorcsan J, Vargas SO, Saggar R, Saggar R, Wallace WD, Ross DJ, Haley KJ, Waxman AB, Parikh VN, De Marco T, Hsue PY, Morris A, Simon MA, Norris KA, Gaggioli C, Loscalzo J, Fessel J, Chan SY

Simple functional imaging of the right ventricle in pulmonary hypertension: Can right ventricular ejection fraction be improved?

International journal of cardiology

Vanderpool RR, Rischard F, Naeije R, Hunter K, Simon MA

Update in Pulmonary Vascular Disease 2015.

American journal of respiratory and critical care medicine

Maron BA, Gladwin MT, Simon MA

Research Priorities in Submassive Pulmonary Embolism: Proceedings from a Multidisciplinary Research Consensus Panel.

Journal of vascular and interventional radiology : JVIR

Sista AK, Goldhaber SZ, Vedantham S, Kline JA, Kuo WT, Kahn SR, Kabrhel C, McLaughlin VV, White SB, Kim NH, Gray M, Simon MA, Benenati JF, Misra S, Sterling KM, Kee ST, Konstantinides SV, Jaff MR, Kearon C

The Prognostic Utility of a Simplified Biventricular Echocardiographic Index of Cardiac Remodeling in Patients with Pulmonary Hypertension.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

Goda A, Ryo K, Delgado-Montero A, Tayal B, Handa R, Simon MA, Gorcsan J

Characterization of right ventricular remodeling in pulmonary hypertension associated with patient outcomes by 3-dimensional wall motion tracking echocardiography.

Circulation. Cardiovascular imaging

Ryo K, Goda A, Onishi T, Delgado-Montero A, Tayal B, Champion HC, Simon MA, Mathier MA, Gladwin MT, Gorcsan J

MY APPROACH to the patient with right ventricular failure.

Trends in cardiovascular medicine

Simon MA

Methods for using 3-D ultrasound speckle tracking in biaxial mechanical testing of biological tissue samples.

Ultrasound in medicine & biology

Yap CH, Park DW, Dutta D, Simon M, Kim K

Elevated pulse pressure is associated with hemolysis, proteinuria and chronic kidney disease in sickle cell disease.

PloS one

Novelli EM, Hildesheim M, Rosano C, Vanderpool R, Simon M, Kato GJ, Gladwin MT

Non-invasive screening for cardiac allograft vasculopathy: go small or go home?

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Teuteberg JJ, Simon MA

RV-pulmonary arterial coupling predicts outcome in patients referred for pulmonary hypertension.

Heart (British Cardiac Society)

Vanderpool RR, Pinsky MR, Naeije R, Deible C, Kosaraju V, Bunner C, Mathier MA, Lacomis J, Champion HC, Simon MA

Treatment for pulmonary arterial hypertension-associated right ventricular dysfunction.

Annals of the American Thoracic Society

Gomez-Arroyo J, Sandoval J, Simon MA, Dominguez-Cano E, Voelkel NF, Bogaard HJ

Structural and mechanical adaptations of right ventricle free wall myocardium to pressure overload.

Annals of biomedical engineering

Hill MR, Simon MA, Valdez-Jasso D, Zhang W, Champion HC, Sacks MS

A comparative analysis of global shape analysis methods for the assessment of the human right ventricle

Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization

Wu J, Simon MA, Brigham JC

An implementation of independent component analysis for 3D statistical shape analysis

Biomedical Signal Processing and Control

Wu J, Brigham KG, Simon M, Brigham JC

Biocompatibility Assessment of the CentriMag-Novalung Adult ECMO Circuit in a Model of Acute Pulmonary Hypertension.

ASAIO journal (American Society for Artificial Internal Organs : 1992)

Shankarraman V, Kocyildirim E, Olia SE, Kameneva MV, Dzadony RJ, Maul TM, Simon MA, Champion HC, Wagner WR, Bermudez CA

Isolated right ventricular dysfunction in patients with human immunodeficiency virus.

Journal of Cardiac Failure

Simon MA, Lacomis CD, George MP, Kessinger C, Weinman R, McMahon D, Gladwin MT, Champion HC, Morris A

Advances in Pulmonary Hypertension

Nitric Oxide Therapeutics in Pulmonary Vascular Disease

Simon MA

First successful lung transplantation for sickle cell disease with severe pulmonary arterial hypertension and pulmonary veno-occlusive disease.

Pulmonary circulation

George MP, Novelli EM, Shigemura N, Simon MA, Feingold B, Krishnamurti L, Morrell MR, Gries CG, Haider S, Johnson BA, Crespo MM, Bhama JK, Bermudez C, Yousem SA, Toyoda Y, Champion HC, Pilewski JM, Gladwin MT

Matrix metalloproteinases in right ventricular failure.

Nature reviews. Cardiology

Simon MA

Myocardial extracellular volume fraction quantified by cardiovascular magnetic resonance is increased in diabetes and associated with mortality and incident heart failure admission.

European Heart Journal

Wong TC, Piehler KM, Kang IA, Kadakkal A, Kellman P, Schwartzman DS, Mulukutla SR, Simon MA, Shroff SG, Kuller LH, Schelbert EB

Standing the test of time: exercise testing for heart failure prognosis in the beta-blocker era.

Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir

Simon M, Soran O

A new computational framework for anatomically consistent 3D statistical shape analysis with clinical imaging applications

Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization

Wu J, Wang Y, Simon MA, Sacks MS, Brigham JC

Assessment and treatment of right ventricular failure.

Nature reviews. Cardiology

Simon MA

Effectiveness of late gadolinium enhancement to improve outcomes prediction in patients referred for cardiovascular magnetic resonance after echocardiography.

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

Wong TC, Piehler K, Puntil KS, Moguillansky D, Meier CG, Lacomis JM, Kellman P, Cook SC, Schwartzman DS, Simon MA, Mulukutla SR, Schelbert EB

Physiologic changes in a nonhuman primate model of HIV-associated pulmonary arterial hypertension.

American journal of respiratory cell and molecular biology

George MP, Champion HC, Simon M, Guyach S, Tarantelli R, Kling HM, Brower A, Janssen C, Murphy J, Carney JP, Morris A, Gladwin MT, Norris KA

Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short-term mortality.

Circulation

Wong TC, Piehler K, Meier CG, Testa SM, Klock AM, Aneizi AA, Shakesprere J, Kellman P, Shroff SG, Schwartzman DS, Mulukutla SR, Simon MA, Schelbert EB

A murine experimental model for the mechanical behaviour of viable right-ventricular myocardium.

The Journal of physiology

Valdez-Jasso D, Simon MA, Champion HC, Sacks MS

Prognosis of right ventricular failure in patients with left ventricular assist device based on decision tree with SMOTE.

IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society

Wang Y, Simon M, Bonde P, Harris BU, Teuteberg JJ, Kormos RL, Antaki JF

Survival benefit of implantable cardioverter-defibrillators in left ventricular assist device-supported heart failure patients.

Journal of Cardiac Failure

Refaat MM, Tanaka T, Kormos RL, McNamara D, Teuteberg J, Winowich S, London B, Simon MA

Decision tree for adjuvant right ventricular support in patients receiving a left ventricular assist device.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Wang Y, Simon MA, Bonde P, Harris BU, Teuteberg JJ, Kormos RL, Antaki JF

Impact of renal function before mechanical circulatory support on posttransplant renal outcomes.

The Annals of thoracic surgery

Singh M, Shullo M, Kormos RL, Lockard K, Zomak R, Simon MA, Bermudez C, Bhama J, McNamara D, Toyoda Y, Teuteberg JJ

Left ventricular mechanical dyssynchrony in acute onset cardiomyopathy: association of its resolution with improvements in ventricular function.

JACC. Cardiovascular imaging

Tanaka H, Tanabe M, Simon MA, Starling RC, Markham D, Thohan V, Mather P, McNamara DM, Gorcsan J

Right ventricular dysfunction and failure in chronic pressure overload.

Cardiology research and practice

Simon MA, Pinsky MR

Role of cardiac resynchronization in end-stage heart failure patients requiring inotrope therapy.

Journal of Cardiac Failure

Bhattacharya S, Abebe K, Simon M, Saba S, Adelstein E

Early adverse events as predictors of 1-year mortality during mechanical circulatory support.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Genovese EA, Dew MA, Teuteberg JJ, Simon MA, Bhama JK, Bermudez CA, Lockard KL, Winowich S, Kormos RL

Right ventricular adaptation to pressure overload.

Current opinion in critical care

Simon MA

Detection of elevated right atrial pressure using a simple bedside ultrasound measure.

American heart journal

Simon MA, Kliner DE, Girod JP, Moguillansky D, Villanueva FS, Pacella JJ

Pulsatile left ventricular assist device support as a bridge to decision in patients with end-stage heart failure complicated by pulmonary hypertension.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Nair PK, Kormos RL, Teuteberg JJ, Mathier MA, Bermudez CA, Toyoda Y, Dew MA, Simon MA

Left ventricular remodeling and myocardial recovery on mechanical circulatory support.

Journal of Cardiac Failure

Simon MA, Primack BA, Teuteberg J, Kormos RL, Bermudez C, Toyoda Y, Shah H, Gorcsan J, McNamara DM

Tissue Doppler imaging of right ventricular decompensation in pulmonary hypertension.

Congestive heart failure (Greenwich, Conn.)

Simon MA, Rajagopalan N, Mathier MA, Shroff SG, Pinsky MR, López-Candales A

Incidence and patterns of adverse event onset during the first 60 days after ventricular assist device implantation.

The Annals of thoracic surgery

Genovese EA, Dew MA, Teuteberg JJ, Simon MA, Kay J, Siegenthaler MP, Bhama JK, Bermudez CA, Lockard KL, Winowich S, Kormos RL

Identifying left ventricular dysfunction in pulmonary hypertension.

Congestive heart failure (Greenwich, Conn.)

Rajagopalan N, Simon MA, Edelman K, Mathier MA, López-Candales A

Phenotyping the right ventricle in patients with pulmonary hypertension.

Clinical and translational science

Simon MA, Deible C, Mathier MA, Lacomis J, Goitein O, Shroff SG, Pinsky MR

Insights into the effects of contraction dyssynchrony on global left ventricular mechano-energetic function.

Pacing and clinical electrophysiology : PACE

Johnson L, Simon MA, Pinsky MR, Shroff SG

Noninvasive estimation of pulmonary vascular resistance in pulmonary hypertension.

Echocardiography (Mount Kisco, N.Y.)

Rajagopalan N, Simon MA, Suffoletto MS, Shah H, Edelman K, Mathier MA, López-Candales A

Utility of right ventricular tissue Doppler imaging: correlation with right heart catheterization.

Echocardiography (Mount Kisco, N.Y.)

Rajagopalan N, Simon MA, Shah H, Mathier MA, López-Candales A

Hemodynamic information and analysis of cardiac pumping

Journal of Mechanics in Medicine and Biology

Hung TK, Balasubramanian SR, Simon MA, Suffoletto M, Borovetz HS, Gorcsan J

Current and future considerations in the use of mechanical circulatory support devices.

Annual review of biomedical engineering

Simon MA, Watson J, Baldwin JT, Wagner WR, Borovetz HS

Identifying right ventricular dysfunction with tissue Doppler imaging in pulmonary hypertension.

International journal of cardiology

Rajagopalan N, Simon MA, Mathier MA, López-Candales A

Right ventricular function following cardiac resynchronization therapy.

The American journal of cardiology

Rajagopalan N, Suffoletto MS, Tanabe M, Miske G, Thomas NC, Simon MA, Bazaz R, Gorcsan J, López-Candales A

Correlation of tricuspid annular velocities with invasive hemodynamics in pulmonary hypertension.

Congestive heart failure (Greenwich, Conn.)

Rajagopalan N, Saxena N, Simon MA, Edelman K, Mathier MA, López-Candales A

Right ventricular dyssynchrony in heart failure: a tissue Doppler imaging study.

Journal of Cardiac Failure

Rajagopalan N, Dohi K, Simon MA, Suffoletto M, Edelman K, Murali S, López-Candales A

Differential exercise performance on ventricular assist device support.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Simon MA, Kormos RL, Gorcsan J, Dohi K, Winowich S, Stanford E, Carozza L, Murali S

Myocardial recovery using ventricular assist devices: prevalence, clinical characteristics, and outcomes.

Circulation

Simon MA, Kormos RL, Murali S, Nair P, Heffernan M, Gorcsan J, Winowich S, McNamara DM

Peak oxygen consumption and outcome in heart failure patients chronically treated with beta-blockers.

Journal of Cardiac Failure

Shakar SF, Lowes BD, Lindenfeld J, Zolty R, Simon M, Robertson AD, Bristow MR, Wolfel EE

Inotropes in the beta-blocker era.

Clinical cardiology

Lowes BD, Simon MA, Tsvetkova TO, Bristow MR

Affiliation: 
Faculty